A few hundred protesters gathered on the approach roads to the Aviva Stadium in opposition to this Sunday's game between Ireland and Israel in Serbia.
The Nations League football match against Austria was also twice briefly interrupted by demonstrations.
In the 19th minute, spectators threw tennis balls covered in Palestinian flag stickers onto the field.
The players left the pitch for a few minutes before the match resumed.
In the 35th minute, a man ran onto the pitch waving a Palestinian flag, briefly interrupting the match again.
The game ended in a 2-2 draw.
Former Republic of Ireland Manager Brian Kerr was among those who stood with supporters from the Stop the Game Campaign and the Ireland-Palestine Solidarity Campaign ahead of the match.
Demonstrators held up banners and flags opposing the Ireland and Israel match.
However, the majority of those approaching the Aviva Stadium before kick-off were fans who had come to see tonight's Nations League game against Austria.
There was a heavy garda presence, but security checks seemed to be in line with other games, despite reports of airport style security being in operation for the game.
Supporters were handed leaflets that fold out into a Palestinian flag and they have been asked to hold them up on a number of occasions during the game.
The groups say the protest, which started at the junction of Lansdowne Road, Northumberland Road and Pembroke Road around 6.30pm, is calling for the Ireland and Israel fixture not to go ahead.
During the game, play was paused after a number of tennis balls were thrown onto the pitch in the 19th minute of the game.
The gesture was greeted with boos in some parts of the ground.
As play returned in the 21st minute some fans held up paper Palestinian flags, but most people appeared to be concentrating on the game itself.
Stop the Game said the limited tennis ball protest is being called the '1948 Protest' - and is a "symbolic act of solidarity with the Palestinian people and a reminder that the Nakba of 1948 began a process of dispossession, violence and genocide that continues in Gaza today".
"The protest is now over. It was a token act, deliberately limited, but necessary and done in solidarity with Gavin Bazunu and the people of Palestine facing genocide," the campaign said.
Later in the half, a pitch invader entered the field of play holding a Palestine flag.
Yesterday, the Stop the Game campaign sent an open letter to the Republic of Ireland squad and their manager Heimir Hallgrimsson not to play the home game that was moved abroad and is being played behind closed doors.
They have also called on the Government and FAI to take the burden off the players by making the decision not to fulfil the fixture.
