Harry Byrne and Max Deegan have been ruled out of Leinster's trip to Durban to face the Sharks in Hollywoodbets Kings Park on Saturday.
Both players suffered concussions in Leinster's one-point defeat to the Lions in their season opener in Johannesburg and will follow graduated return-to-play protocols this week.
Back row Josh Ericson is a doubt for the Sharks clash after suffering a neck injury which requires further assessment.
Jack Boyle (Achilles), RG Snyman (knee), Caelan Doris (Foot & Knee), Paddy McCarthy (foot), Jamison Gibson-Park (Groin), Jordan Larmour (calf), Diarmaid Mangan (foot), James Culhane (hamstring) are still recovering from longer term injuries and will not be involved this weekend.